Coagulation Factor Inhibitor, Plasma |
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Mixing studies are used as a screening test to detect the presence of a coagulation factor inhibitor (see under "Anticoagulant, Circulating"). Inhibitors of factor VIII coagulant activity are the most common of the specific factor inhibitors. Factor VIII inhibitors arise in patients whom are congenitally deficient in factor VIII (hemophilia A) in response to factor replacement therapy, but can also occur spontaneously in various immunologic disorders, in the post-partum period, with use of certain antibiotics, in some malignancies, and in advanced age. If the screening assay indicates the presence of an inhibitor, it will be quantitated and reported in Bethesda units The specimen requirement is one 5mL blue top (citrate) tube.
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