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Crystal Identification, Synovial Fluid

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Birefringent crystals are found in the synovial fluid of >90% of patients with acutely inflamed joints. Crystal identification aids in the diagnosis of joint disease. Monosodium urate crystals are seen in gouty fluids. Urate crystals are mainly needle-shaped and strongly doubly refractile, and may be found within leukocytes. Calcium pyrophosphate crystals are present in chondrocalcinosis. They are usually rhomboidal and weakly birefringent. Cholesterol crystals may also be observed as bright square or rectangular plates.