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AntiCardiolipin (Anti-phospholipid) Antibody

The presence of anticardiolipin antibody (ACA) has been associated with recurrent arterial and venous thrombosis, recurrent fetal loss, thrombocytopenia, neurologic events including transient ischemic attack (TIA) and stroke, and dermatologic disease, primarily livedo reticularis. In addition to testing for lupus anticoagulant, immunologic methods can be used to detect anticardiolipin antibody.

Diagnostic criteria for the antiphospholipid syndrome include both clinical and laboratory findings. At least one of the following clinical criteria must be met; arterial or venous thrombosis, pulmonary hypertension, livedo reticularis, TIA or stroke, recurrent fetal loss, or thrombocytopenia. Laboratory findings must include positive tests for lupus anticoagulant and/or anticardiolipin antibody. Anticardiolipin antibody and lupus anticoagulant tests are discordant in approximately 30% of patients. Positive results with either of these assays should be regarded as independent risk fac

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