Clinlab Navigator

Nephrin Autoantibody

Minimal change disease (MCD) is a common cause of the nephrotic syndrome in children and adults, but the underlying pathogenesis is unclear. In a recent study of over 60 adults and children with biopsy-proven MCD and no known genetic basis, circulating autoantibodies targeting nephrin, a component of the glomerular slit diaphragm, were identified in approximately one-third of patients with active disease. Punctate immunoglobulin G (IgG) deposits colocalized with nephrin in the kidney biopsies of patients who were serologically positive for anti-nephrin antibodies, whereas no deposits were present in those who were serologically negative. These findings suggest a possible autoimmune etiology for MCD in a subset of patients. Reference

Watts A, Keller K, Lerner G, et al. Discovery of Autoantibodies Targeting Nephrin in Minimal Change Disease Supports a Novel Autoimmune Etiology. J Am Soc Nephrol 2021.

Updated Articles


Melioidosis is a bacterial infection caused by Burkholderia pseudomallei, which was formerly known as Pseudomonas pseudomallei. B. pseudomallei is a Gram-negative bacterium that typically lives in soil and water in regions with tropical and…

New Articles


Fentanyl is a synthetic opioid analgesic that is widely used in surgical operations. Because it is 50 to 100 times more potent than morphine, fentanyl is also used for pain management in patients who no longer respond to high doses of morphine or…


Avian Influenza H5N1

Avian influenza refers to disease in birds caused by infection with avian influenza Type A viruses. These viruses occur naturally among wild aquatic birds worldwide and can infect domestic poultry and other bird and animal species. Wild aquatic…