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Pregabalin

Pregabalin (Lyrica) is an anticonvulsant drug used to treat partial seizures. Pregabalin is also commonly prescribed to treat neuropathic pain and fibromyalgia. Measurement of the concentration of Pregabalin in serum is helpful in assessing compliance and monitoring patients with renal failure who generally require lower dosages.

Therapeutic concentration is 2 to 5 ug/mL when measured by liquid chromatography plus mass spectrometry. Toxicity may occur at serum concentrations greater than 10 ug/mL. Specimen requirement is a red top tube of blood.

Hiemke, C, Baumann P, Bergemann N, et al: AGNP Consensus Guidelines for Therapeutic Drug Monitoring in Psychiatry: Update 2011. Pharmacopsychiatry 2011;44:195-235

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Carbapenem Resistance

The Enterobacteriaceae are a large family of gram-negative bacilli that includes Escherichia coli, Klebsiella species, and Enterobacter species. They are normal inhabitants of the gastrointestinal tract of humans and animals and a common cause of…

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Riboflavin

Riboflavin is also called Vitamin B2. Riboflavin deficiency is called ariboflavinosis and is primarily caused by reduced dietary intake. Symptoms include sore throat, cheilosis, angular stomatitis, glossitis, corneal vascularization, dermatitis, and…

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Hashtags for…

Twitter has become a very active social media site for all subspecialties of Pathology. Recently, Symplur published a list of Pathology Tag Ontology, which was developed by the USCAP Social Media Subcommittee. Pathology Tag Ontology is a…

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Cases That Kept Me Up At Night: Case #1

Case #1 is an overview of transfusion reactions and a discussion of a neonate with both NAIT and Rh HDN.

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