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Pregabalin

Pregabalin (Lyrica) is an anticonvulsant drug used to treat partial seizures. Pregabalin is also commonly prescribed to treat neuropathic pain and fibromyalgia. Measurement of the concentration of Pregabalin in serum is helpful in assessing compliance and monitoring patients with renal failure who generally require lower dosages.

Therapeutic concentration is 2 to 5 ug/mL when measured by liquid chromatography plus mass spectrometry. Toxicity may occur at serum concentrations greater than 10 ug/mL. Specimen requirement is a red top tube of blood.

Hiemke, C, Baumann P, Bergemann N, et al: AGNP Consensus Guidelines for Therapeutic Drug Monitoring in Psychiatry: Update 2011. Pharmacopsychiatry 2011;44:195-235

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Osmolality

Osmolality is a colligative property and is a measure of the total number of particles in a solution. Colligative properties affect the freezing point, boiling point, and vapor pressure of any solution. Increasing the osmolality reduces the…

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Babesia microti

Babesiosis is an emerging zoonotic disease caused primarily by Babesia microti, an intraerythocytic protozoan. Babesia microti is endemic to the northeastern and upper midwestern United States where it is usually transmitted by the blacklegged tick,…

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Eculizumab…

Eculizumab (Soliris, Alexion Pharmaceuticals) is a recombinant humanized monoclonal antibody (IgG2/4 kappa) that was designed to block the activation of terminal complement components. It is licensed in the United States for treatment of paroxysmal…

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Cases That Kept Me Up At Night: Case #1

Case #1 is an overview of transfusion reactions and a discussion of a neonate with both NAIT and Rh HDN.

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