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The question and answer section is a repository of user generated questions regarding material posted on this web site. We encourage visitors to submit questions and we will attempt to provide prompt responses via e-mail and this Q & A database. Sharing ideas will allow all of us to navigate our laboratories through calmer seas.



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Blood Bank (8)Chemistry (13)Flow Cytometry (0)
General Site (2)Hematology (8)Method Evaluation (2)
Microbiology (1)Molecular Diagnostics (0)Phlebotomy (1)
Quality Control (2)Toxicology (1)Transfusion (2)
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Top 5 Articles
What is the normal range for early morning creatinine to cortisol ratio? I am intending to use it as a screening tool for hypercortism and can only seen to find ref ranges for animals!
You ask what is the normal range for early morning creatinine to cortisol ratio. It is not clear if you are planning to measure cortisol in plasma or urine. I am ......
●●●●● Last Update: 2007-11-02 Views: 13
I read that 25% of raynaud's phenomenom patients have centromere antibodies. Does this mean that these patients are at risk for scleroderma or just that centromere antibodies are associated with raynaud's by itself?
Raynaud phenomenon is diagnosed either by physical examination or by eliciting a specific clinical history. An ANA test does not help establish the diagnosis, but may provide prognostic information. Raynaud phenomenon ......
Not Rated Last Update: 2007-11-02 Views: 12
A patient with an RH weakly positive begin transfusion with RH positive blood unit. The transfusion was discontinued because later the Medical Technologist check that the protocol recommend that recipient Du positive ( weakly positive Rh) needs to be transfused with blood RH negative. The protocol said that a weakly positive RH person shoul d be considered as RH negative recipient and as RH positive donor. The patient is fine. No change in his test before and after the transfufion. Should this even be consdered a Sentinel event that has to be reported to the JCHA ect.?
Historically, if a patient typed as Rh negative, additional testing was then performed to determine if they had Rh Du or weak D expression. In the past several years, weak D ......
Not Rated Last Update: 2007-11-02 Views: 10
What are the hematologic manifestations of congenital infections? e.g. CMV, toxoplasmosis. We have a 3 month old patient with myocarditis, microcephaly, rash and hemolytic anemia. Toxic changes and thrombocytosis seen on smear... Is this consistent with a dx of congenital CMV or congenital Toxoplasmosis? And if untreated, what is the course of these hematologic changes? When do they return to normal?
Laboratory findings in congenital toxoplasmosis include leukocytosis, predominately due to an increase in lymphocytes and reactive lymphocytes. The most common hematologic complication is hemolytic anemia.   The most common hematologic findings ......
●●●●● Last Update: 2007-11-02 Views: 9
Dear staff, I have learned the following from your website: 1- ristocetin cofactor: platelet from healthy donor + plasma from patient + ristocetin 2- ristocetin induced platelet aggregation: platelet from patient + plasma from patient + ristocetin 3- ristocetin cofactor is more sensitive and specific than RIPA I ask: a- what is the difference between two exams after all? b- why ristocetin cofactor is more sensitive and specific than RIPA?
R CoF tests only the patient\'s plasma (VWF activity) against fixed platelets whereas RIPA tests patient\'s plasma and platelets. That would account for greater specificity. I\'m not sure of the reason ......
Not Rated Last Update: 2007-12-02 Views: 5
Last 5 Articles
I am researching for my IV course and essay and need to know what drugs, if any, can be added to a blood transfusion.
The 23rd edition of AABB Standards for Blood Banks and Transfusion Services and the Circular of Information for the Use of Human Blood and Blood Components that is published by ......
Not Rated Last Update: 2008-07-22 Views: 1
I would like some references on the information published here about Platelet transfusion, specifically about the ABO-nonidentical platelets. In several places, it appears nonidentical is not consistently used. A product may be "nonidentical" but compatible. Under the section: Platelet ABO Compatibility, the 2nd and 3rd paragraph are specifically the information are I would like referenced.
See the attached Word document for all references....
Not Rated Last Update: 2008-07-15 Views: 3
What drugs may result in a false positive urine test for benzodiazipene?
The most commonly reported drugs associated with a falsely positive benzodiazepine are anti-inflammatory medications such as Daypro. Some antihistamines have also shown crossreactivity at very high concentrations....
Not Rated Last Update: 2008-07-15 Views: 1
I have a technical question. My CSF lab came back with a Myelin Basic Protein reading of 30.28 with the reference interval 0.07-4.10 mg/L. Note that the units were 'mg/L' and not 'ng/mL' Could it be that the computer automatically converted the figure to 30 (instead of .03) because of the the units being set to mg/L ? Have you ever seen something like this happen in these test printouts?
Results reported in mg/L and ng/mL should differ by a factor of 1000. I wonder if the laboratory that performed your tests is really reporting results in ug/L, but their report ......
Not Rated Last Update: 2008-07-08 Views: 1
Is there a published reference for the information in Test Significant Change?
Many references have been published on this topic. The articles that I have found to be most useful are listed below.   Ross JW, Lawson NS. Analytic Goals, concentration relationships, and ......
Not Rated Last Update: 2008-07-08 Views: 1