CMV Negative Blood Components |
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Transfusion acquired CMV is of little concern in immunocompetent individuals, but can be a serious problem in immunocompromised patients. In the latter group of patients, CMV transmission can result in pneumonitis, chronic hepatitis, gastroenteritis, chorioretinitis, or disseminated disease. CMV negative blood components are indicated for patients in the first two groups in the table below. Indications for CMV negative units have not yet been well established for the third group of patients. If a hospital is practicing universal leukoreduction, it is not necessary to also provide CMV negative units. At certain hospitals, CMV negative components are used for fetal and neonatal transfusions.
Indications for the Transfusion CMV Negative Products
Established Indications
- All fetal and intrauterine transfusions.
- Low birth weight premature infants born to CMV seronegative mothers (all neonates at SLH).
- CMV negative recipients of organ or bone marrow transplants from CMV negative donors.
- CMV negative bone marrow transplant recipients.
- Antepartum transfusions for CMV negative women.
Less Well Established Indications
- CMV negative patients with HIV.
- CMV negative patients who are potential candidates for autologous or allogeneic bone marrow transplant.
- CMV negative patients undergoing splenectomy.
- Potential seronegative donors for bone marrow transplant.
Unestablished Indications
- CMV negative BMT recipients from CMV positive donors.
- CMV positive BMT recipients.
- CMV negative solid organ transplants from CMV positive donors.
- CMV positive recipients of solid organ transplants.
Depending on need, a blood center screens a certain percentage of donated units for CMV IgG and IgM antibody. Seronegative donors serve as a continuous supply of CMV negative products. The CMV status of these donors is reconfirmed with each donation. Administration of CMV negative units is the same as regular units of red blood cells and platelets.
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