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Vitamin E

Vitamin E is a tocopherol that functions as an antioxidant, protecting the integrity of lipid membranes and preventing oxidative damage to retinol. Vitamin E deficiency can be caused by conditions that cause fat malabsorption such as cholestatic liver disease, pancreatic insufficiency and small intestinal resection or disease. Deficiency of Vitamin E in adults and children causes reversible neuropathy and hemolysis..

Specimen requirement is a red top tube of blood.  Patient should be fasting overnight to prevent falsely elevated concentrations.  Vitamin E is measured in serum by liquid chromatography combined with tandem mass spectrometry.

Vitamin E levels below 5.0 ug/mL are considered deficient. Levels greater than 40 mg/L indicate excessive vitamin E. 

Updated Articles

Platelet Transfusion…

The most common reasons for transfusing platelets are decreased platelet production, increased platelet destruction and qualitative platelet defects. A high proportion of platelets are transfused prophylactically to reduce the risk of spontaneous…

New Articles

Factor VIII…

Factor VIII is a large glycoprotein cofactor with a molecular weight of 320 kilodaltons that is synthesized mainly in hepatocytes, but also in hepatic macrophages, megakaryocytes, and endothelial cells. Factor VIII circulates in plasma bound to von…

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Asymptomatic…

Asymptomatic microscopic hematuria (AMH) is a common problem that can occasionally be a marker of severe disease such as urinary tract cancer. AMH is defined as 3 or more red blood cells per high-powered field on urine microscopy. In patients who…

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Lectures

Cases That Kept Me Up At Night: Case #1

Case #1 is an overview of transfusion reactions and a discussion of a neonate with both NAIT and Rh HDN.

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