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Von Willebrand Factor Antigen

von Willebrand factor (vWF) is a large multimeric glycoprotein that circulates in the blood noncovalently bound to factor VIII coagulant protein. In von Willebrand’s disease, abnormalities of vWF, ristocetin cofactor, and factor VIII coagulant activity are demonstrable.

VWF antigen is measured by ELISA. Decreased levels are found in type 1 and type III von Willebrand’s Disease. VWF levels can be normal or decreased in Type II VWD.

Reference range is 52 - 175%.

Specimen requirement is one light blue top (sodium citrate) tube of blood. Tests for ristocetin cofactor and factor VIII activity are recommended in conjunction with von Willebrand Factor antigen. See also von Willebrand’s Disease and von Willebrand Disease Panel for more information. 

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