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Acute Hemolytic Transfusion Reaction

Today, it is estimated that 1 in 38,000 red cell units is transfused to the wrong patient. When the wrong unit of viagra cheap fast shipping blood is given, it is ABO-incompatible 1 in 3 times. Two thirds of these erroneous transfusions are caused by a clerical or management error in identifying the patient, blood sample or blood component and omnitron-systems.com one third are due to buy viagra online safe an error in the transfusion service. Of these ABO-incompatible transfusions, about 10% are associated with a fatal hemolytic transfusion reaction. Occasionally, a non-ABO antibody may also trigger acute intravascular hemolysis. Very rarely, an antibody from transfused donor plasma may be implicated in an acute hemolytic reaction.

Etiology: The pathophysiology of acute hemolytic reactions involves 3 phases.

  • In the first phase, IgM or IgG antibody binds to the transfused red blood cell membranes. If these antibodies are capable of activating complement (C1 to C9), hemolysis occurs.
  • In phase 2, the red cells that are no

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