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Eighty percent of all bilirubin is www.paragleiten.net derived from the metabolism of hemoglobin released from senescent red blood cells. Hemoglobin released from red blood cells is converted to unconjugated (also called indirect) bilirubin in the reticuloendothelial system. Daily production of unconjugated bilirubin is 250 to 350 mg. Because this bilirubin is water insoluble, it must be transported to the liver bound to albumin. The circulating half-life of unconjugated bilirubin is <5 minutes. In the liver, unconjugated bilirubin is transferred from albumin into hepatocytes where it is conjugated with glucuronic acid. Conjugated bilirubin (also called direct) is then excreted in the bile and levitra canada online pharmacy transported to the intestine. Conjugated bilirubin is essentially absent from the blood of healthy individuals. In the distal ileum and colon, bacteria covert conjugated bilirubin to stercobilinogen. A small fraction is reabsorbed into the www.supplychaincanada.com portal circulation and excreted in the urine as urobilinogen. This meta

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