1. Skip to Menu
  2. Skip to Content
  3. Skip to Footer

Dexamethasone Suppression Test For Depression

Failure of suppression of cortisol secretion by dexamethasone is useful in identifying patients with endogenous depression.The patient takes one mg of dexamethasone at 23:00 hours. The next day plasma cortisol determinations are drawn at 16:00 and 23:00 hours. The patient should be medically healthy and physiologically stable when the test is performed.

A plasma cortisol concentration in either sample of greater than 5 ug/dL is considered a positive test. Several anticonvulsant and sedative‑hypnotic drugs cause false positive tests by accelerating the rate of metabolism of dexamethasone: phenytoin, barbiturates, meprobamate, glutithimide, methyprylon, methaqualone, and carbamazepine. False negative tests are associated with hypopituitarism, adrenal cortical insufficiency, steroid therapy, indomethacin, and high dose cyproheptadine treatment.

Specimen requirement is one SST tube at each time containing a minimum of 2 mL of blood.

AddThis Social Bookmark Button

Stay Informed

Amazon Book

Our Sponsors

Login Form

Mobile Applications

iPad mini Horz Vert 300w

Get it for: iPhoneiPad

ClinLab Navigator Information

McAfee SECURE sites help keep you safe from identity theft, credit card fraud, spyware, spam, viruses and online scams
© 2015 ClinLab Navigator, LLC.