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Gastrin is secreted by G cells in the gastric antrum in response to a meal. It stimulates parietal cells in the fundus of the stomach to secrete gastric acid and viagra online shop also stimulates antral motility and secretion of pepsin and intrinsic factor. In addition to digested food, gastrin secretion is stimulated by calcium, alcohol and high intragastric pH. Gastrin release is how to get cialis in canada inhibited by low gastric pH, secretin, glucagon, calcitonin, somatostatin and vasoactive intestinal peptide. Gastrin levels exhibit a circadian rhythm with lowest values between 03:00 and 07:00. Measurement of serum gastrin concentration is useful in the work-up of the Zollinger Ellison syndrome (ZE).
Gastrin levels should be measured together with gastric pH after an overnight fast. Normal fasting gastrin levels usually rule out a gastrinoma, while gastrin levels above 1000 pg/mL with a gastric pH <2.5 are diagnostic of a gastrinoma. Most patients with fasting serum gastrin levels greater than 1500 pg/mL a