1. Skip to Menu
  2. Skip to Content
  3. Skip to Footer

Histone Antibody

Histones are basic proteins, which bind to DNA within the nuclei of all cells. IgG antibodies to H2A-H2B histones are found in nearly all patients with symptomatic procainamide induced lupus, 19% of asymptomatic patients treated with procainamide, and 20% of SLE patients. Hydralazine induced lupus is also associated with anti-histone antibodies, with specificity for H3 and H4 histones. Anti-histone antibodies have also been found in patients with rheumatoid arthritis, juvenile rheumatoid arthritis, scleroderma, vasculitis, and undifferentiated rheumatic disease syndromes.

A positive ANA is necessary to make a diagnosis of drug induced lupus, but detection of histone antibody does not provide much additional information that cannot be provided by clinical findings.

Reference value is absent.

Specimen requirement is one SST tube of blood.

AddThis Social Bookmark Button

Stay Informed

Amazon Book

Our Sponsors

Login Form

Mobile Applications

iPad mini Horz Vert 300w

Get it for: iPhoneiPad

ClinLab Navigator Information

McAfee SECURE sites help keep you safe from identity theft, credit card fraud, spyware, spam, viruses and online scams
© 2015 ClinLab Navigator, LLC.