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Lamotrigine (Lamictal) is an antiepileptic drug that is widely used for treatment of partial seizures and bipolar disorder. Lamotrigine is the preferred antiepileptic drug to treat pregnant women experiencing seizures.

Circulating half life ranges from 15 to 35 hours. Drug metabolism is induced over time. Drug clearance is higher in children and much higher in pregnancy.

Common adverse effects include dizziness, drowsiness, insomnia, headache, blurred or double vision, ataxia, tremor and rash. Serious adverse events include Stevens Johnson syndrome and toxic epidermal necrolysis.

Therapeutic range is 3-14 ug/mL for treatment of refractory epilepsy. Toxic effects are more common when the plasma concentration exceeds 15 ug/mL, but some patients tolerate concentrations up to 70 ug/mL

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