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Leukocyte Alkaline Phosphatase (LAP)

Historically, the diagnostic utility of leukocyte alkaline phosphatase (LAP) activity (measured as the LAP score) was in the differential diagnosis of leukocytosis (Leukocyte Alkaline Phosphatase in Hematology 4th ed. McGraw-Hill: New York 1990). The LAP score was usually low in chronic myeloid leukemia (CML), which helped distinguish CML from other myeloproliferative neoplasms with leukocytosis and no prescription viagra inflammatory leukemoid reactions, both of which had a normal or increased LAP score. Additionally, it was noted that the LAP score was also low in patients with paroxysmal nocturnal hemoglobinuria (PNH), although this was not used as a diagnostic test for PNH. In the laboratory, the LAP score is determined using a cytochemical stain on a peripheral blood film followed by a semiquantitative visual estimation of the degree of staining in neutrophils. Thus, the test is inherently limited in its reproducibility and accuracy. Finally, even before the viagra sale prices molecular pathogenesis of viagra generic now CML and PNH was

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