- Last Update On : 2013-01-26
Platelet size can be measured directly by automated hematology analyzers, expressed as mean platelet volume (MPV). Platelet size is determined at the time of platelet production from megakaryocytes. There is evidence that MPV is increased when both platelet production and destruction are increased, probably mediated by cytokines such as interleukin-3, interleukin-6, and thrombopoietin. There is also evidence that larger platelets are functionally more reactive, produce more thromboxane A2, aggregate more readily in vitro, contain more dense granules, and show increased expression of membrane receptors.
Elevated MPV has been associated clinically with cardiovascular and cerebrovascular morbidity. Elevated MPV has been identified as an independent risk factor for myocardial infarction in patients with coronary heart disease (Brit J Haematol, 2002, 1178,399-404), and for death or recurrent ischemic events after myocardial infarction (Lancet, 1991, 338:1409-1411). MPV has also b