- Last Update On : 2013-02-03
Hereditary hemochromatosis is the most common genetic disorder in the US white population and enter site is transmitted as an autosomal recessive trait. One in every 250 to 300 persons is homozygous for the hemochromatosis mutation and at least 1 in every 10 persons is a carrier for the mutation. The most common genetic abnormality is the C282Y mutation of the www.fanclubdenhaag.nl HFE gene, which is soft cialis believed to cialis united states have originally occurred in a Celtic ancestor. Most persons diagnosed with hereditary hemochromatosis are C282Y homozygotes (60-100%), while a small proportion (0–4%) is homozygous for a second mutation, H63D. Approximately 0–7% of patients are found to be compound heterozygotes (C282Y/H63D).
Hereditary hemochromatosis is associated with increased small intestinal iron absorption and progressive tissue deposition. Between the ages of 40 and 60, excessive iron accumulation may result in cirrhosis, heart failure, arrhythmia, diabetes, impotence, arthropathy, and skin bronzing. However, if hemochro