FT4 may be estimated indirectly by calculating T7, which is the product of T4 x T3U. This calculation is an attempt to correct for variations in thyroxine binding proteins. T7 will usually be elevated in patients with hyperthyroidism and decreased with hypothyroidism. It may be low in patients with nonthyroid illness.

Disorder

Total T4

T3 Uptake

T7

Primary hypothyroid

Decreased

Decreased

Decreased

Secondary hypothyroid

Decreased

Decreased

Decreased

Hyperthyroid

Increased

Increased

Increased

T3 Toxicosis

Normal

Normal

Normal

Direct measurement of free T4 is recommended instead of T7.

Reference range is 1.22 - 4.86 for males and 0.99 - 4.71 for females.

Specimen requirement is one SST tube of blood.


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